Nipro Laser-based Glass Cutting Technology

The applied glass cutting technology in the converting process of prefillable syringes (PFS) has major influence on glass particles generation, mechanical finger flange properties and the consistency of the syringe dimensions. Nipro PharmaPackaging  has addressed this point by implementing the innovative technology of laser-based glass cutting in the converting process of the Nipro PFS.

Benefits

Improved Total Cost of Ownership

  • Less risk of rejections at F/F sites as as result of less particles¹
  • Lower risk of finger flange breakages during F/F operations due to increased mechanical flange stability
  • Lower risk of market recalls due to glass particulates or device functional failures

 

Enhanced Patient Safety

  • Lower risk of glass particulates inside PFS
  • Safer drug delivery devices due increased finger flange stability

 

Optimized Integration between Auto-Injection Devices and PFS

Smoother assembly operations due to tighter dimensional parameters for finger flanges

Study results

Glass Particles¹:

  • Sub-visible range: -62%
    Significant reduction of glass sub visible particles with Nipro laser-based cutting compared to traditional cutting
  • Visible range: -100%
    No visible particles found with with Nipro laser-based cutting

Finger Flanges (1 ml long syringe)

  • Dimensional accuracy (thickness):
    Nipro laser-based cutting: 1.85 mm ±0.1 mm (Traditional cutting: 1.67 mm +0.3 / -0.2 mm)
  • Strength:
    Strength of finger flanges with laser based cut compared to traditional cut: AVG: +40% NM | MIN: +57% NM

If you would like to learn more: 

Watch the webinar on-demand | April 2017

 

Article published  in the “Pharmaceutical Manufacturing and Packing Sourcer (PMPS)2 | February 2017

 

Presentation given during the PDA – Universe of Pre-Filled Syringes & Injection Devices | October 2016

 

1 Source: Study performed in collaboration with „Zentrum für Glas- und Umweltanalytik GmbH“ (Centre for glass investigations and environmental analysis)
2 This article is taken from Pharmaceutical Manufacturing and Packing Sourcer February 2017, pages 42-46. © Samedan Ltd

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